Zonisamide and topamax and weight loss
Acute pancreatitis, rhabdomyolysis, increased creatine phosphokinase, and drug reaction with. ZONEGRAN who experienced an event on at least one occasion. Adverse Reactions in Placebo-Controlled, Add-On Trials (Events that occurred in at least 2% of ZONEGRANtreated. (April 2016). Chemically, topiramate is a sulfamate -substituted monosaccharide, related to fructose, a rather unusual chemical structure for an anticonvulsant. As is the case for all antiepileptic drugs, it is advisable not to suddenly discontinue topiramate as there is a theoretical risk of rebound seizures. The frequencies represent the proportion of the 1,598 individuals exposed to. Infrequent: Hypertonia, twitching, abnormal dreams, vertigo, libido decreased, neuropathy, hyperkinesia. Topiramate (brand name Topamax ) is an anticonvulsant (antiepilepsy) drug. Please review the contents of the article and add the appropriate references if you can. Six metabolites have been identified in humans, none of which constitutes more than 5% of an administered dose. The following serious adverse reactions have been reported since approval and use of ZONEGRAN. In late 2012, topiramate was approved by the United States Food and Drug Administration (FDA) in combination with phentermine for weight loss. Avoid activities requiring mental alertness and coordination until drug effects are realized. This medication was discovered in 1979 by Bruce E. Although topiramate does inhibit high-voltage-activated calcium channels, the relevance to clinical activity is uncertain. The most common adverse reactions leading to discontinuation were somnolence. The drug had previously been used off-label for this purpose. People taking topiramate should be aware of the following risks. Discontinuation of topiramate may halt the progression of the ocular damage, and may reverse the visual impairment.
Use caution with activities leading to an increased core temperature, such as strenuous exercise, exposure to extreme heat, or dehydration. Hypoglycemia, hyponatremia, lactic dehydrogenase increased, SGOT increased, SGPT increased. Rare: Dyskinesia, dystonia, encephalopathy, facial paralysis, hypokinesia, hyperesthesia. Infrequent: Urinary frequency, dysuria, urinary incontinence, hematuria, impotence, urinary. Most of the drug (70%) is excreted in the urine unchanged. The most common adverse reactions with ZONEGRAN (an incidence at least 4% greater than placebo). Some of the most common are listed below. In controlled clinical trials, 12% of patients receiving ZONEGRAN as adjunctive therapy discontinued. The remainder is extensively metabolized by hydroxylation, hydrolysis, and glucuronidation. Events are further classified within each category and listed in order of decreasing frequency as. This article needs more medical references for verification or relies too heavily on primary sources. Topiramate may decrease effectiveness of estrogen-containing oral contraceptives. Table 4. Infrequent: Peripheral edema, weight gain, edema, thirst, dehydration. Unsourced or poorly sourced material may be challenged and removed. Table 4 lists adverse reactions that occurred in at least 2% of patients treated with ZONEGRAN in. Formication (the sensation of insects crawling under the skin). ZONEGRAN has been administered to 1,598 individuals during all clinical trials, only some of which. Alcohol may cause increased sedation or drowsiness, and increase the risk of having a seizure.
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zonisamide and topiramate weight loss
Zonisamide and topamax and weight loss
